. 2000 Oct 24;97(22):11707–11713. doi: 10.1073/pnas.97.22.11707

Table 2.

Frequencies of various phenotypes in inner ears of Otx1 and Otx2 mutants

Genotype	No. of animals	Lack of lateral canal and ampulla	Lack of separation of utricle and saccule	Lack or aberrant cochleo saccular duct	Aberrant saccule	Misshapen cochlea
Genotype	No. of animals	Lack of lateral canal and ampulla	Lack of separation of utricle and saccule	Lack or aberrant cochleo saccular duct	Aberrant saccule	Hook region	No. of coils	Aberrant shape
Otx1 −/−	11	11	11	11	6	11	9	5
Otx1 −/− Otx2 +/−	9	9	9	9	7	9	8	7
hOtx2¹/hOtx2¹	7	7	6	5	0	5	1	0
Otd¹/Otd¹	6	6	6	5	6	5	0	0
hOtx1²/hOtx1²	10	0	9	9	10	10	9	10

All mutant mice were scored between 15 to 16.5 dpc. At these stages, the cochlea should coil from 1.5 to a mature 1.75 turns. Any cochlea that had 1.5 turns was considered normal in order to accommodate for variability in staging and possible developmental delay of mutants.