Table III. Ingenuity Pathway Analysis of the differentially expressed membrane proteins associated with canonical pathways.

Differentially expressed proteins from supplemental Table IA were used for the analysis and are shown in bold type. Only the top three pathways are shown.

Canonical pathways	Associated molecules	p value	Ratio
Acute phase response signaling	HPX, FTL, ORM1/ORM2, C3, APOH, APOA1, APOA2, C9, CP, F2, FGG, PLG, ALB, HP, ITIH2, TF, C4B (includes others), FGB, A2M	4.27 E-09	19/172
Caveolar-mediated endocytosis signaling	ITGB1, B2M, ITGB2, ALB, ITGAM, HLA-A, ITSN1, FLNA, FLNC, ITGA5, EGFR, HLA-C	4.57 E-08	12/81
Calcium signaling	RAP2A, CALR, MYL6, ITPR2, TPM2, SLC8A2, ATP2B2, CAMK2A, CAMK2D, PRKAR2B, PPP3R1, MYH9, ASPH, TPM4, PPP3CA, CAMK2G, CAMK2B	1.47 E-07	17/185