Fig. 3.

Bioinformatic analysis of the HSP90 regulated proteome part I. A, Results of GO term enrichment analysis of all four cell lines (colored). B, Example results of Ingenuity Pathway Analysis (IPA) across the geldanamycin regulated proteomes of the four cell lines analyzed. The histogram bars indicate the degree (significance) of overrepresentation of a particular pathway in a particular cell line. C, Binary protein-protein interaction map of HSP90alpha and HSP90beta extracted by IPA from the list of geldanamycin regulated proteins. Orange edges and nodes indicate down-regulation, black ones indicate up-regulation upon drug treatment (see supplemental Fig. S16 for a high resolution map).