Fig. 2.
Plasma cytokine and chemokine profiles. Plasma concentrations of TNF (A), IL-6 (B), KC (C), MCP-1 (D), and IL-10 (E) at 48 h after inoculation (T1) with 103 CFU of E. coli or PBS in aged mice. Septic mice were classified as septic without acute kidney injury (S) or septic with acute kidney injury (S+AKI). The combined results of independent experiments are shown (n = 5–7 mice for each group). Data are means±S.D. *, p < 0.05 and **, p < 0.01 compared with age-matched PBS controls; #, p < 0.05 compared with S mice.