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. 2012 Jul 21;4(7):462–479. doi: 10.18632/aging.100471

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Copyright: © 2012 Calnan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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(A) In vitro methylation of the N-terminal portion of FoxO3 (amino acids 1-300) by 8 different methyltransferases. ◁: FoxO3 methylated by Set9, *: Set9 auto-methylation. (B) In vitro methylation of the C-terminal portion of FoxO3 (amino acids 301-673) by 8 different methyltransferases. *: Set9 auto-methylation. (C) Methylation of the full-length FoxO3 protein by Set9. ◁: full-length FoxO3, ◀: FoxO3 degradation product, *: Set9 auto-methylation.