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Ad5 and the high dose of INGN 007 caused bone marrow damage in hamsters. With hamsters injected with the high dose of RC viruses, changes in hematological parameters indicate damage to the bone marrow. At day 7, erythrocyte counts (a), hematocrit (b) and hemoglobin concentration (c) decreased significantly in Ad5- or high-dose INGN 007-injected hamsters, whereas red cell distribution width (d) increased at day 29 in these animals. N: population size, *P<0.05.
