Figure 4.

Maximal density and total amount of progenitor cells on a crypt as functions of removal rate of BMP or maximal death rate of TD cells. (A) Blue: removal rate of BMP versus maximal density of progenitor cells (max (C₀)); green: removal rate of BMP versus total amount of progenitor cells. (B) Blue: maximal death rate of TD cells (${\overline{d}}_1$) versus maximal density of progenitor cells (max (C₀)); green: maximal death rate of TD cells versus the total amount of progenitor cells. (C) Spatial distribution of progenitor cells and the spatial crypt pattern at ${\overline{d}}_1=0.02$ and 0.2. Other parameters used for the simulation are in Additional file 1: Table S2.