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. 2012 Sep;140(3):307–324. doi: 10.1085/jgp.201210826

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© 2012 Garg et al.

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Figure 9. — ICA activates F359L hEAG1 channels and inhibits F359L/Y464A hEAG1 channels. (A) F359L hEAG1 currents recorded under control conditions and after the application of 10 µM ICA. (B) F359L/Y464A hEAG1 currents recorded under control conditions and after the application of 10 µM ICA. In all panels, currents were elicited with two-pulse inactivation protocol: V_h = −100 mV, and V_pre (10 s) ranged from −130 to +20 mV, applied in 15-mV increments. A test pulse to +30 mV was applied after each V_pre.