Figure 1.

Large TAAs induce a characteristic partial block of K⁺ current in RyR2 channels. Single channel recordings of purified, EMD 41000–activated RyR2 channels at a holding potential of 60 mV with 610 mM K⁺ as the charge carrier. Addition of large TAAs (200 µM TBA, 100 µM TPeA, and 10 µM THexA) results in the occurrence of well-resolved blocking events.