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. 2012 Sep;140(3):325–339. doi: 10.1085/jgp.201210851

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© 2012 Mason et al.

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Figure 10. — Effect of lowering the hydrophobicity of TM10 residues on the block of ryanodine-modified RyR2 channels by MHBPI. Representative single channel traces at a holding potential of 50 mV in symmetrical 210 mM KCl. MHBPI was applied to the cytosolic (cis) side of the RyR2 channels. Closed, open, and blocked levels are indicated by dashed lines. In each case, A shows representative activity of a ryanodine-modified channel before application of 20 µM MHBPI. B shows activity of the same channel after addition of the peptide.