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. 2012 Sep;140(3):325–339. doi: 10.1085/jgp.201210851

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© 2012 Mason et al.

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Figure 8. — The probability of block (1 − P_o), rates of association/dissociation (k_on/k_off), and the affinity (K_d) of TPeA in EMD 41000–activated WT and substituted RyR2 channels. (A–D) Blocking parameters were determined at 60 mV in the presence of 100 µM TPeA. Data are plotted as mean values (±SEM; n = 5–7; *, P < 0.05; **, P < 0.01; ***, P < 0.001).