Figure 2. K562 cells overexpressing LMW-PTP are less sensitive towards vincristine.

(A) LMW-PTP was overexpressed in K562 and its expression was examined in the total lysate of leukemia cells. (B) K562 cells overexpression LMW-PTP (K562^LMW-PTP) or not (K562^WT) were treated with VCR 125 nM for 24 h and the viable cells were counted. Each value represents the mean ± S.D. of three independent experiments (n = 3). ***p<0.001, *p<0.5 - significant differences relative to control (no VCR) or as indicated in the graph.