Table 2. Cannabis approach-bias activations: main task effect across groups and correlation lifetime cannabis use and change problem severity (CUDIT-scores) at six-month follow-up in heavy cannabis users.

Clustersize	Brain region	Hemisphere	MNI coordinates			Z max
(voxels)			x	y	z
Main effect approach vs. avoid
787	Ventral medial frontal gyrus	R/L	−6	56	−14	4.55
578	Posterior cingulate gyrus	R/L	10	−56	20	3.50
Lifetime cannabis use positive correlation
3801	Parahippocampal gyrus	L	−14	−34	−8	3.96
	Amygdala	R	16	−4	−18	3.40
	Occipital cortex	L/R	−6	−58	2	3.62
	Cerebellum	R	34	−40	−30	3.76
1598	Cerebellum	L	−34	−72	−28	3.83
2221	Insula	R	38	10	2	3.78
	Inferior frontal gyrus, pars opercularis	R	52	16	4	3.16
1082	Medial frontal gyrus	L/R	6	56	−4	3.21
686	Precuneus	R	4	−62	60	3.83
495	Supramarinal gyrus, BA 40	L	−54	−48	24	3.41
Change CUDIT negative correlation
413	Dorsolateral prefrontal cortex	R	36	32	36	3.54
746	Anterior cingulate cortex	L/R	−8	42	18	3.34

L, left; R, right; MNI, Montreal Neurological Institute; BA, Brodmann Area; MNI coordinates and Z-scores of local maxima are shown for each cluster; Statistical threshold: Z >2.3, whole-brain cluster-corrected at p<0.05.