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. 2012 Sep 5;7(9):e43973. doi: 10.1371/journal.pone.0043973

Figure 1. Inhibition of IKK activity in the BLA after retrieval impairs the reconsolidation.

Figure 1

(A) Outline of the experimental procedure. (B) Freezing time in response to the CS after training was comparable across groups that received bilateral intra-BLA infusion of SSZ or vehicle (vehicle, n = 11; 1.25 mM SSZ, n = 9; 2.5 mM SSZ, n = 10). (C) Freezing behavior after bilateral intra-BLA infusion of SSZ or vehicle in the 4 h test was comparable across groups, but the 24 h SSZ (2.5 mM/side) infusion group exhibited significant amnesia. (D) Freezing time in response to the CS after training was comparable across groups that received an intra-CeA infusion of SSZ or vehicle (vehicle, n = 8; 2.5 mM SSZ, n = 10). (E) Freezing behavior test after intra-CeA infusion of SSZ or vehicle in the 4 h and 24 h tests (p>0.05). The data are expressed as mean ± SEM. *p<0.01, compared with pre-C; # p<0.01, compared with vehicle group (two-way ANOVA followed by post hoc test).