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Angiotensin (Ang) II treatment increased plasminogen activator inhibitor (Pai)-1 mRNA levels in cardiac (A), renal (B), and aortic (C) tissue in wild-type (WT) mice. Spironolactone (SPL) or genetic aldosterone synthase deficiency (As-/-) prevented this increase within the heart and aorta, and attenuated the effect within the kidney. *P<0.05 vs. WT-vehicle; †P<0.05 vs. WT-Ang II; ‡P<0.05 vs. As-/--Vehicle-SPL.
