Table 5.
Sensitivity Analysis of All-Cause Mortality Using Different eGFR Adjustments in 4,132 Participants of NHANES 1999–2002 with cystatin C Measurements (491 deaths)
| Relative Hazard (95% CI) | |||
|---|---|---|---|
| Anion Gap | Unadjusted | CKD-EPI eGFR | Cystatin C eGFR |
| Traditional | |||
| Continuous* | 1.11 (0.92–1.35) | 1.14 (0.95–1.36) | 1.11 (0.93–1.32) |
| Quartile 1 | Ref | Ref | Ref |
| Quartile 2 | 0.74 (0.48–1.13) | 0.83 (0.53–1.29) | 0.80 (0.52–1.23) |
| Quartile 3 | 0.90 (0.55–1.50) | 0.96 (0.57–1.61) | 0.94 (0.57–1.54) |
| Quartile 4 | 1.14 (0.77–1.69) | 1.26 (0.86–1.86) | 1.18 (0.81–1.72) |
| P for trend | 0.33 | 0.15 | 0.24 |
| Albumin adjusted | |||
| Continuous* | 1.34 (1.09–1.64) | 1.24 (1.05–1.47) | 1.20 (1.01–1.42) |
| Quartile 1 | Ref | Ref | Ref |
| Quartile 2 | 0.75 (0.45–1.25) | 0.76 (0.47–1.26) | 0.77 (0.48–1.24) |
| Quartile 3 | 0.92 (0.57–1.49) | 0.90 (0.56–1.44) | 0.87 (0.56–1.36) |
| Quartile 4 | 1.69 (1.12–2.55) | 1.42 (0.96–2.10) | 1.34 (0.92–1.94) |
| P for trend | 0.009 | 0.03 | 0.07 |
| Full | |||
| Continuous* | 1.45 (1.16–1.80) | 1.26 (1.06–1.51) | 1.23 (1.02–1.47) |
| Quartile 1 | Ref | Ref | Ref |
| Quartile 2 | 0.65 (0.37–1.14) | 0.65 (0.39–1.08) | 0.65 (0.39–1.07) |
| Quartile 3 | 0.89 (0.54–1.49) | 0.80 (0.48–1.32) | 0.76 (0.47–1.23) |
| Quartile 4 | 1.81 (1.16–2.84) | 1.33 (0.88–2.00) | 1.24 (0.83–1.84) |
| P for trend | 0.004 | 0.05 | 0.11 |
Abbreviations: CI, Confidence Interval; eGFR, estimated glomerular filtration rate.
Bold values indicate p<0.05.
Quartile cutoff levels for each anion gap definition: Traditional: Q1 ≤11; Q2 11.1–13; Q3 13.1–14.6; Q4 ≥14.7mEq/L; Albumin adjusted: Q1 ≤0.2; Q2 0.25–1.95; Q3 2.00–3.60; Q4 ≥3.65 mEq/L; Full: Q1 <4.41; Q2 4.41–6.24; Q3 6.25–7.94; Q4 ≥7.95 mEq/L.
Per standard deviation higher anion gap (traditional SD = 2.55 mEq/L; Albumin adjusted SD = 2.47 mEq/L; Full SD = 2.49 mEq/L).
Models are unadjusted, or adjusted for age, sex, race/ethnicity, and CKD-EPI or eGFRcys categories, as noted in the Table.