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. Author manuscript; available in PMC: 2013 Nov 3.
Published in final edited form as: J Phys Chem B. 2012 May 3;116(19):5588–5594. doi: 10.1021/jp300546u

Figure 1.

Figure 1

(A) Schematic of single molecule FRET experiments. GQ forming DNA constructs are immobilized on a poly ethylene glycol coated quartz slide via a neutravidin biotin linker. Adding potassium stabilizes the GQ structure whereas RPA unfolds the structure. (B) Sequences and a possible folding conformation for each of the three GQ constructs studied in this work. TH-2 and TH-4 are located within the promoter region of the tyrosine hydroxylase gene and they can form a two and four layer GQ, respectively. TR-3 is the human telomeric repeat that forms a three layer GQ.