Table I. Summary of cytokine responses to LPS and Nac in cortex, hippocampus, and serum.

Cytokines that were significantly elevated following LPS treatment and unaffected by Nac are marked with a single asterisk, two asterisks indicate that elevations induced by LPS were significantly inhibited by Nac, and three asterisks indicate that LPS-induced elevations were significantly potentiated by Nac. An absence of asterisk indicates baseline levels were either undetectable (brain IL-10, INF-gamma, eotaxin) or detectable but that LPS had no effect (serum IL-13). All data were analyzed by one way ANOVA with Newman-Keuls multiple comparisons test, n=8–10 per group, p-value cutoff was 0.05.

Cytokine/Chemokine	Serum	Cortex	Hippocampus
IL-1α	*	*	*
IL-1β	*	*	*
IL-6	*	*	*
IL-10	**
IL-12 (p40)	*	*	*
IL-13		*	*
Eotaxin (CCL11)	*	*
IFN-γ	**
MIP-1α	*	*	*
MIP-1β	**	**	**
G-CSF	*	*	*
KC (CXCL1)	*	*	***
MCP-1 (CCL2)	**	*	*
RANTES (CCL-5)	**	*	*