Table 3.

Associations between chronic fatigue syndrome and NHL subtypes^a

	CFS1: ICD-9 300.5 or ICD-9-CM 780.71 (1992–2005)				CFS2: ICD-9-CM 780.71 (1999 or later)
	Total	% with CFS1	OR, 95% CIb,c	P-value	Total	% with CFS2	OR, 95% CIb,c	P-value
Controls	100,000	0.5	1.0 (reference)		65,465	0.7	1.0 (reference)
Overall NHL	57,632	0.7	1.29 ( 1.16, 1.43)	1.7E-06	39,142	0.8	1.22 ( 1.09, 1.37)	0.0005
Burkitt	273	--	0.59 ( 0.08, 4.17)	0.594	224	--	0.66 ( 0.09, 4.66)	0.673
CLL/SL/PLL	15,456	0.6	1.22 ( 1.00, 1.49)	0.054	10,360	0.8	1.16 ( 0.93, 1.44)	0.183
Mantle cell	1,619	0.7	1.27 ( 0.70, 2.30)	0.428	1,225	--	1.30 ( 0.70, 2.42)	0.412
DLBCL	16,470	0.7	1.34 ( 1.12, 1.61)	0.002	11,354	0.9	1.21 ( 0.99, 1.47)	0.070
Follicular	7,493	0.6	1.17 ( 0.88, 1.57)	0.283	5,175	0.8	1.23 ( 0.91, 1.67)	0.174
LPL/Waldenstrom	727	--	1.00 ( 0.37, 2.68)	1.000	509	--	1.11 ( 0.42, 2.98)	0.831
Marginal zone	3,358	1.2	1.88 ( 1.38, 2.57)	6.5E-05	2,799	1.3	1.89 ( 1.36, 2.62)	1.3E-04
NHL, NOS	2,097	--	1.45 ( 0.78, 2.70)	0.244	830	--	1.16 ( 0.55, 2.45)	0.688
B-cell NHL, NOS	2,930	0.9	1.51 ( 1.03, 2.23)	0.037	2,184	1.1	1.48 ( 0.98, 2.24)	0.062
T-cell NHL	2,933	0.4	0.80 ( 0.45, 1.41)	0.437	2,014	--	0.59 ( 0.29, 1.18)	0.138
LN, NOS	4,238	0.4	0.92 ( 0.59, 1.44)	0.716	2,446	0.7	0.94 ( 0.58, 1.51)	0.785

Abbreviations: DLBCL = diffuse large B-cell lymphoma; CLL = chronic lymphocytic leukemia; SLL = small lymphocytic lymphoma; PLL = prolymphocytic leukemia; LPL = lymphoplasmacytic lymphoma; B-cell NHL NOS = B-cell NHL, not otherwise specified; T-NHL = T-cell NHL; NHL NOS = NHL of unknown lineage; LN, NOS = lymphoid neoplasm, not otherwise specified; OR = odds ratio; CI = confidence interval: ICD-9 = International Classification of Disease, 9th edition

^aNumbers of exposed cancer cases between 1 and 10 were suppressed in accordance with the SEER-Medicare data use agreement

^bOdds ratios were adjusted for age, sex and selection year

^cOdds ratios for precursor lymphoblastic leukemia/lymphoma, B-cell were not estimable