Figure 7.

Genes associated with Myd88 deficiency are not enriched in tracheal epithelial stem and progenitor cells. Differentially expressed genes identified in our microarray studies (Figure 6A and Supporting information, Supplementary Table 1) were compared with publicly available tracheal epithelial stem and progenitor cell gene expression profiles (GSE15724). (A, B) Uninjured Myd88KO tracheal gene expression relative to wild-type samples is plotted logarithmically on the X-axis. Up- and down-regulated genes are depicted by filled and clear diamonds, respectively. Each gene was also plotted along the Y-axis according to its enrichment in defined tracheal stem (A) or progenitor (B) cells relative to a negatively staining cell population. We only considered genes exhibiting a minimum two-fold enrichment in either tracheal stem or progenitor cell populations (shaded areas, A and B). Using these criteria, only three out of 103 transcripts identified in our studies were additionally enriched in tracheal stem and progenitor cells