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. 2012 Sep 6;2:637. doi: 10.1038/srep00637

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Copyright © 2012, Macmillan Publishers Limited. All rights reserved

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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(a) HA-tagged SOCS3 was overexpressed in miR122-silenced Huh7 cells. Representative blotting images are shown. (b) SOCS3 overexpression suppresses enhanced ISRE activities in miR122-silenced Huh7 cells by a reporter assay. *, p < 0.05. Data represent the means ± SD of three independent determinations. (c) SOCS3 overexpression restored STAT2 and STAT3 phosphorylation levels induced by IFN-α in miR122-sileced Huh7 cells. A representative of three independent determinations is shown. The band intensities were quantitated and adjusted by the expression levels of β-actin. The calculated ratios are indicated below each panel after setting the value of control cells at 0 h as 1.0.