Table 1. Top 30 genes with promoters differentially methylated in control and miR122-silenced Huh7 cells. Values indicate methylation levels. Values in ‘Differences' indicate quantitative differences in methylation levels of target gene CpG sites. Higher values indicate greater methylation levels. Genes in bold and highlighted in gray means greater methylation; others were less methylated in miR122-silenced Huh7 cells.
SYMBOL | Control | miR122-silenced | Difference | CpG ISLAND LOCATIONS |
---|---|---|---|---|
GPC3 | 0.4242135 | 0.11596 | 0.3082535 | X:132946499-132947763 |
FLJ30058 | 0.4155016 | 0.1428133 | 0.2726883 | X:130019792-130020537 |
EIF3S6IP | 0.672594 | 0.4012034 | 0.2713906 | 22:36574299-36576077 |
BHLHB9 | 0.3481071 | 0.07687688 | 0.27123022 | X:101862184-101862707 |
PORCN | 0.6389685 | 0.3697215 | 0.269247 | |
MSI2 | 0.4593301 | 0.1955636 | 0.2637665 | 17:52688030-52689554 |
DNTT | 0.6114385 | 0.3489618 | 0.2624767 | 10:98054238-98054478 |
SEMA3B | 0.3901392 | 0.1301293 | 0.2600099 | 3:50285369-50286362 |
RYR2 | 0.4331115 | 0.1756537 | 0.2574578 | 1:235271651-235273428 |
TCEAL7 | 0.6519198 | 0.4006093 | 0.2513105 | |
NR0B2 | 0.3711949 | 0.1234481 | 0.2477468 | |
SOCS3 | 0.1831344 | 0.4273662 | 0.2442318 | 17:73866027-73868731 |
TAS2R16 | 0.5821649 | 0.3380581 | 0.2441068 | |
BHLHB9 | 0.3021148 | 0.06171004 | 0.24040476 | X:101862184-101862707 |
OR12D3 | 0.5266486 | 0.2884241 | 0.2382245 | |
ADAMTSL1 | 0.4537211 | 0.2196532 | 0.2340679 | |
TBX6 | 0.5031447 | 0.2695281 | 0.2336166 | 16:30010427-30011656 |
ICAM4 | 0.4990334 | 0.2668367 | 0.2321967 | 19:10258558-10259935 |
C9orf125 | 0.2387415 | 0.4707038 | 0.2319623 | 9:103287963-103289481 |
ELN | 0.1332373 | 0.3629701 | 0.2297328 | 7:73080116-73080605 |
ANKRD30A | 0.898423 | 0.6711555 | 0.2272675 | 10:37453955-37454965 |
OR10J1 | 0.5324367 | 0.3094136 | 0.2230231 | |
TP73 | 0.3596564 | 0.1386476 | 0.2210088 | 1:3596889-3597535 |
CNNM1 | 0.6313883 | 0.4106784 | 0.2207099 | 10:101078809-101080801 |
DHH | 0.2955738 | 0.07619943 | 0.21937437 | 12:47774151-47774653 |
CTAG2 | 0.5303309 | 0.3110451 | 0.2192858 | X:153536438-153536702 |
GNB4 | 0.3091451 | 0.09039365 | 0.21875145 | 3:180651316-180652496 |
PNPLA2 | 0.4458646 | 0.2272328 | 0.2186318 | 11:808884-809164 |
FGF7 | 0.6298472 | 0.4128944 | 0.2169528 | |
NTE | 0.4557684 | 0.2400911 | 0.2156773 | 19:7504300-7507429 |