Figure 4.

Omega-3 PUFA enriched diet does not affect the sensitivity of brain mitochondria respiratory parameters to IsoKs. (a) Respiratory parameters measured in different metabolic states state 2 (V ₂), state 3 (V ₃), state 4 (V ₄), FCCP-stimulated respiration (V _unc). Glutamate/malate was used as the substrate. IsoKs were added to mitochondria after the addition of substrate. (b) The dependence of the RCRs on omega-3 dietary content. The data are expressed in μmol O₂/min/mg protein and are the mean ± SEM, n = 6. Statistical significance in oxygen consumption between tested samples was determined by a two-sample t-test.