Table 4.

Type I error rates for rare variant association methods.

Method	Type I error rate
DMAF sq rare	0.067
DMAF abs rare	0.057
DMAF abs all	0.053
C-alpha rare	0.067
C-alpha all	0.053
Hotel	0.020
CMC	0.067
aSum	0.053
KBAC	0.030
RVT1	0.043
VT	0.040
WSS	0.037

Type I error rate calculated for null simulations across regions 1, 2, and 3 at a nominal α = 0.05.