Table 2.
Genes that are significantlya decreased in expression across WT, KLF1−/−, and KLF1−/− KLF2−/− embryonic erythroid cells
| Gene symbol | Description | P value | AffyID |
|---|---|---|---|
| Elavl2 | ELAVc | 0.000518 | 1421883_at |
| Gmpr3 | GMPR | 0.000518 | 1448530_at |
| Zdhhc14 | Zinc finger, DHHC domain containing 14 | 0.000518 | 1438619_x_at |
| Arrb1 | Arrestin, beta 1 | 0.000518 | 1460444_at |
| Sgk3 | Serum/glucocorticoid regulated kinase 3 | 0.000518 | 1420918_at |
| Cd24ab | CD24a antigen | 0.000797 | 1437502_x_at |
| Memo1 | Mediator of cell motility 1 | 0.000797 | 1420339_at |
| Klf1 | KLF1 (erythroid) | 0.000797 | 1418600_at |
| 1600012F09Rik | RIKEN cDNA 1600012F09 gene | 0.000797 | 1419660_at |
| Hdac11 | Histone deacetylase 11 | 0.000797 | 1451229_at |
| Pvt1 | Plasmacytoma variant translocation 1 | 0.001211 | 1452324_at |
| Eraf | Erythroid-associated factor | 0.001211 | 1449077_at |
| Tfrc | TFRC | 0.001211 | 1452661_at |
| Pklr | PKLR | 0.001211 | 1438711_at |
| Orc2l | Origin recognition complex, subunit 2 like (Saccharomyces cerevisiae) | 0.001211 | 1418226_at |
| Mmaa | Methylmalonic aciduria (cobalamin deficiency) type A | 0.001211 | 1417857_at |
| Dhh | Desert hedgehog | 0.001211 | 1434959_at |
| Icam4 | Intercellular adhesion molecule 4, Landsteiner-Wiener blood group | 0.001211 | 1422930_at |
| Epb4.9 | Erythrocyte protein band 4.9 | 0.001211 | 1460223_a_at |
| Chchd10 | Coiled-coil-helix-coiled-coil-helix domain containing 10 | 0.001211 | 1436990_s_at |
| Nudt19 | Nudixd-type motif 19 | 0.001812 | 1432332_a_at |
| Wdr43 | WD repeat domain 43 | 0.001812 | 1428390_at |
| Ankrd28 | Ankyrin repeat domain 28 | 0.001812 | 1454801_at |
| Kcnn4 | Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | 0.001812 | 1435945_a_at |
| Mphosph10 | M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) | 0.001812 | 1429080_at |
| Nudcd1 | NudC domain containing 1 | 0.001812 | 1429655_at |
| Nudt19 | Nudix-type motif 19 | 0.001812 | 1434216_a_at |
| Pth1r | Parathyroid hormone 1 receptor | 0.001812 | 1417092_at |
| Usp59 | Ubiquitin-specific peptidase 49 | 0.001812 | 1453037_at |
| Add2 | Adducin 2 (beta) | 0.001812 | 1450442_at |
| Ddx3x | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X linked | 0.001812 | 1416467_at |
| AU021092 | Expressed sequence AU021092 | 0.002673 | 1437661_at |
| BC048403 | cDNA sequence BC048403 | 0.002673 | 1427954_at |
| Asb17 | Ankyrin repeat and SOCS box-containing 17 | 0.002673 | 1420468_at |
| Cldn13 | Claudin 13 | 0.002673 | 1422920_at |
| Zdhhc14 | Zinc finger, DHHC domain containing 14 | 0.002673 | 1437614_x_at |
| Hspa12b | Heat shock protein 12B | 0.002673 | 1460371_at |
| Dnaja4 | DnaJ (Hsp40) homolog, subfamily A, member 4 | 0.002673 | 1418591_at |
| Slc4a1 | Solute carrier family 4 (anion exchanger), member 1 | 0.002673 | 1416464_at |
| Atg5 | Autophagy-related 5 (yeast) | 0.002673 | 1418235_at |
| Myc | Myelocytomatosis oncogene | 0.002673 | 1424942_a_at |
| Pfkp | Phosphofructokinase, platelet | 0.002673 | 1430634_a_at |
| BC048355 | cDNA sequence BC048355 | 0.002673 | 1460713_at |
| Exosc2 | Exosome component 2 | 0.002673 | 1426630_at |
| Nme3 | Nonmetastatic cells 3, protein expressed in | 0.002673 | 1448905_at |
| Irf4 | Interferon regulatory factor 4 | 0.002673 | 1421174_at |
| AA517858 | Expressed sequence AA517858 | 0.003229 | 1420121_at |
| Adcy7 | Adenylate cyclase 7 | 0.003888 | 1456307_s_at |
| BC056474 | cDNA sequence BC056474 | 0.003888 | 1424117_at |
| Hbb-b1/Hbb-b2 | Hemoglobin, beta adult major chain/hemoglobin, beta adult minor chain | 0.003888 | 1417184_s_at |
| Cd24ab | CD24a antigen | 0.003888 | 1416034_at |
| Abcg4 | ATP-binding cassette, subfamily G (WHITE), member 4 | 0.003888 | 1424437_s_at |
| Elavl2 | ELAV | 0.003888 | 1421882_a_at |
| Dck | Deoxycytidine kinase | 0.003888 | 1439012_a_at |
| Ctse | Cathepsin E | 0.003888 | 1418989_at |
| Pklr | PKLR | 0.003888 | 1421258_a_at |
| Ermap | Erythroblast membrane-associated protein | 0.003888 | 1418909_at |
| 2810453I06Rik | RIKEN cDNA 2810453I06 gene | 0.003888 | 1418389_at |
| Zdhhc14 | Zinc finger, DHHC domain containing 14 | 0.003888 | 1438975_x_at |
| 1110007M04Rik | RIKEN cDNA 1110007M04 gene | 0.003888 | 1427997_at |
| Gcnt2 | Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme | 0.003888 | 1430826_s_at |
| 1300017J02Rik | RIKEN cDNA 1300017J02 gene | 0.003888 | 1424722_at |
| Fgf13 | Fibroblast growth factor 13 | 0.003888 | 1418498_at |
| Atp13a2 | ATPase type 13A2 | 0.003888 | 1452747_at |
| Txnrd3 | Thioredoxin reductase 3 | 0.003888 | 1449623_at |
| Myo19 | Myosin XIX | 0.003888 | 1451183_at |
| Cd24a | CD24a antigen | 0.005577 | 1448182_a_at |
| Nop10 | NOP10 ribonucleoprotein homolog (yeast) | 0.005577 | 1423210_a_at |
| Hbb-b2 | Hemoglobin, beta adult minor chain | 0.005577 | 1427866_x_at |
| Slc4a1 | Solute carrier family 4 (anion exchanger), member 1 | 0.005577 | 1434502_x_at |
| Xpo5 | Exportin 5 | 0.005577 | 1451468_s_at |
| Mapk6 | Mitogen-activated protein kinase 6 | 0.005577 | 1419169_at |
| Rhd | Rh blood group, D antigen | 0.005577 | 1417049_at |
| Mgst3 | Microsomal glutathione S-transferase 3 | 0.005577 | 1448300_at |
| Traf6 | Tumor necrosis factor receptor-associated factor 6 | 0.005577 | 1435350_at |
| Clps | Colipase, pancreatic | 0.005577 | 1438612_a_at |
| Dnaja4 | DnaJ (Hsp40) homolog, subfamily A, member 4 | 0.005577 | 1434196_at |
| Tlcd1 | TLC domain containing 1 | 0.005577 | 1452132_at |
| Olfr78 | Olfactory receptor 78 | 0.005577 | 1421507_at |
| Nol5a | Nucleolar protein 5A | 0.005577 | 1455035_s_at |
| Igfals | Insulin-like growth factor binding protein, acid-labile subunit | 0.005577 | 1422826_at |
| Traf4 | Tumor necrosis factor receptor-associated factor 4 | 0.005577 | 1416571_at |
| Rrp1b | rRNA processing 1 homolog B (S. cerevisiae) | 0.005577 | 1452119_at |
| Srfbp1 | Serum response factor binding protein 1 | 0.005577 | 1420509_at |
| Tmem49 | Transmembrane protein 49 | 0.005577 | 1421491_a_at |
| Grin2b | Glutamate receptor, ionotropic, NMDA2B (epsilon 2) | 0.006644 | 1422223_at |
| Usp38 | Ubiquitin-specific peptidase 38 | 0.007888 | 1428592_s_at |
| Bco2 | Beta-carotene oxygenase 2 | 0.007888 | 1421221_at |
| Arl6ip6 | ADP-ribosylation factor-like 6 interacting protein 6 | 0.007888 | 1424021_at |
| Sphk1 | Sphingosine kinase 1 | 0.007888 | 1451596_a_at |
| Frrs1 | Ferric-chelate reductase 1 | 0.007888 | 1423465_at |
| Pigq | Phosphatidylinositol glycan anchor biosynthesis, class Q | 0.007888 | 1437999_x_at |
| Plek2 | Pleckstrin 2 | 0.007888 | 1449424_at |
| Ppara | Peroxisome proliferator-activated receptor alpha | 0.007888 | 1449051_at |
| Ela3 | Elastase 3, pancreatic | 0.007888 | 1415883_a_at |
| Tcp11 | T-complex protein 11 | 0.007888 | 1420730_a_at |
| Unknown | Unknown | 0.007888 | 1425499_at |
| Josd2 | Josephin domain containing 2 | 0.007888 | 1449046_a_at |
| 1810029B16Rik | RIKEN cDNA 1810029B16 gene | 0.007888 | 1423289_a_at |
| Slc25a37 | Solute carrier family 25, member 37 | 0.007888 | 1417750_a_at |
| Pde3a | Phosphodiesterase 3A, cGMP inhibited | 0.007888 | 1431914_at |
| Echdc1 | Enoyl coenzyme A hydratase domain containing 1 | 0.007888 | 1419552_at |
| Csda | Cold shock domain protein A | 0.007888 | 1451012_a_at |
| Pura | Purine-rich element binding protein A | 0.007888 | 1449934_at |
| Btg2 | B-cell translocation gene 2, antiproliferative | 0.007888 | 1448272_at |
| 2610209A20Rik | RIKEN cDNA 2610209A20 gene | 0.007888 | 1423357_at |
| Ndn | Necdin | 0.007888 | 1456575_at |
| Isoc1 | Isochorismatase domain containing 1 | 0.007888 | 1425051_at |
| Foxm1 | Forkhead box M1 | 0.007888 | 1448833_at |
| 1600014C10Rik | RIKEN cDNA 1600014C10 gene | 0.007888 | 1436289_x_at |
a
P < 0.01.
b
Included are the products of 101 unique genes, but some were detected by multiple AffyID probe sets and there are multiple entries for these.
c
ELAV, embryonic lethal, abnormal vision, Drosophila-like 2 (Hu antigen B).
d
Nudix, nucleoside diphosphate-linked moiety X.