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. 2012 Aug;32(16):3347–3357. doi: 10.1128/MCB.00128-12

Fig 3.

Fig 3

Lack of carotid body hypertrophy in SDHD-ESR mice. (A) Levels of SdhD mRNA in kidney and adrenal gland of separate control (flox/+ and flox/− without CRE) groups and mutant individuals 5 days after tamoxifen injection (at P50), demonstrating general loss of SdhD. r. u., relative units. There were 3 to 7 individuals per group. (B) Succinate ubiquinone oxireductase activity (MCII) in mitochondria isolated from kidney cells 3 weeks after tamoxifen injection. There were 3 to 6 individuals per group. (C) Carotid body (CB) immunostained for tyrosine hydroxylase (TH) 3 weeks after tamoxifen injection. Bar, 100 μm. (D) Total and TH+ fraction volumes of carotid bodies from control (n = 3) and SDHD-ESR (n = 4) animals 3 weeks after tamoxifen injection (at P50). *, P < 0.05; ***, P ≤ 0.001.