Table 1C. Studies of neurotoxic and neuroprotective effects of IL-6 in experimental stroke.
| Ischemia model | Strain | Intervention | Results | Effect of IL-6 | Reference |
|---|---|---|---|---|---|
| Mouse | |||||
| Proximal tMCAO (45 minutes, 2 hours, filament) | IL-6-KO IL-6+/− WT LM | — | IL-6 deficiency had no effect on infarct volume | No effect | Clark et al (2000) |
| Proximal tMCAO (1 hour, filament) | IL-6-KO C57BL/6 | — | IL-6-KO mice had increased infarcts when body temperature was controlled to C57BL/6 levels | Neuroprotective | Herrmann et al (2003) |
| Rat | |||||
| Proximal pMCAO (electrocoagulation) | SD | i.c.v. injection of 2 × 50 or 2 × 500 ng rhIL-6 30 minutes before and again 15 minutes after pMCAO | rhIL-6 reduced infarct volumes | Neuroprotective | Loddick et al (1998) |
i.c.v., intracerebroventricular; IL-6, interleukin-6; KO, knock out; pMCAO, permanent middle cerebral artery occlusion; rh, recombinant human; SD, sprague dawley; tMCAO, transient middle cerebral artery occlusion; WT LM, wild-type littermates.