Figure 5.

Summary of Abcc8 gene regulation in central nervous system (CNS) injury. (A, B) In-situ hybridization for Abcc8 mRNA (A) and immunolabeling for sulfonylurea receptor 1 (Sur1) (B) in coronal sections of rat brain after 6-hour middle cerebral artery occlusion (MCAo) followed by 3 hours of reperfusion; from Simard et al (2010a). (C) Transcriptional activation of Abcc8, the gene that encodes Sur1, during hypoxia, mechanical trauma and inflammatory states involves Hif-1, Sp1, and NF-κB. The exact mechanism of activation of Sp1 and NF-κB during mechanical injury remains speculative at this time.