Figure 7.

Inhibition of sulfonylurea receptor 1 (Sur1) prevents brain swelling and death after malignant cerebral infarction. (A to C) Hemispheric swelling (A, B) and death (C) 24 hours after a 6-hour ischemic insult are significantly reduced by administering glibenclamide (GLIB) at 6 hours, at the time of recanalization, compared with vehicle (VEH). (D, E) After a 6-hour ischemic insult, neurologic function, measured using the Garcia scoring system (D), and tissue preservation (E) are significantly better in rats treated with GLIB compared with rats receiving decompressive craniectomy (DC) (both treatments administered at 6 hours, at the time of recanalization); all data from Simard et al (2010a).