Imaging protocol schema. For the oxygen challenge sequences, the values in parenthesis represent duration in minutes of room air (RA), normobaric oxygen (NBO), and RA exposure. ABG, arterial blood gas; ASL, arterial spin label; BOLD, blood oxygenation level-dependent signal; CBV, cerebral blood volume; DWI, diffusion-weighted imaging; GRE, gradient echo imaging; MCAO, middle cerebral artery occlusion; MION, monocrystalline iron oxide nanocolloid.