Fig. 1.

Incidence of liver degeneration (males only), myocardial nuclear atypia, endometrial hyperplasia (females only), and adrenal tumor in young, old, and rapamycin-treated mice. Group sizes were as follows: young, old, and Rapa-Low, 15 of each sex; Rapa-Mid 14 females and 12 males; Rapa-High, 13 females and nine males. Fisher's Exact Test was used to evaluate the significance of age effects (young vs. old untreated), to compare Rapa (all doses) vs. old (untreated), or to compare old untreated vs. Rapa-high as indicated in the figure panels. Cuzick's nonparametric test for trends (Cuzick, 1985) was used to evaluate significance of differences among the four groups of old mice at rapamycin doses (zero, low, mid, or high).