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Age-associated decline of spontaneous in-cage activity, calculated as a change score (× 10–3) for each mouse tested at both 7 and 18 months of age. Bars show means ± SEM, and asterisks indicate significant effects of rapamycin treatment at P < 0.05, as estimated using a two-factor anova with Site (UT, UM, TJL) and Rx (rapamycin or untreated) as the predictor variables.
