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Dose response curves of select kinase inhibitors for rescue of ΔF508-CFTR expressed in the MDCK cells. Average increase in short-circuit currents (ΔIsc) of MDCK cell monolayers stably expressing ΔF508-CFTR (relative to DMSO vehicle control alone) treated for 48 h with 1, 10, 20, 100, 200, 1000, and 10,000 nm of the top inhibitor compounds, indicated in panels (A–K). Data are mean ± S.E. of (n) samples.
