Fig. 1.
Structure and domain organization of Hel308
A. Shown in ribbon is the structure of Hel308 from S. solfataricus. Domain 1 (1-199) is colored grey, domain 2 (200-416) wheat, domain 3 (426-501) purple, domain 4 (501-646) cyan and domain 5 (648-705) red. The extended linker (417-425) connecting domains 2 and 3 is shown in green. A disulfide bond linking the only two cysteines in the structure, C519 and C555, is shown in yellow.
B. Cartoon showing the domain arrangement of Hel308 and the proposed opening of the interface between domains 2 and 4 to allow loading onto DNA.