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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Jul 6;22(17):5685–5688. doi: 10.1016/j.bmcl.2012.06.098

Scheme 1.

Scheme 1

(a) Ar(CH2)nCHO, 8N NaOH, EtOH, rt, 2 h or Ar(CH2)nCHO, conc HCl, MeOH, Δ, 4 h (60 – 75%); (b) R3CO2H, NH2NH2·xH2O, 120 °C, 15 h (70 – 80% when n = 0; 20% when n = 1); (c) H2 (1 atm), 10% Pd/C, EtOH (47–75%); (d) MCPBA, DCM, rt, 16 h (90–96%).