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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Jul 6;22(17):5685–5688. doi: 10.1016/j.bmcl.2012.06.098

Table 1.

Compounds prepared for microsomal stability studies and EC50 determinations for necroptosis inhibition in FADD-deficient Jurkat T cells treated with TNF-α.

graphic file with name nihms392277u1.jpg
Compound R1 R2 R3 R4 X n
2 OMe β-Ha 4-OMe Me CH2 0
20a OMe β-Me 4-OMe Me CH2 0
20b OMe α-Me 4-OMe Me CH2 0
21 OMe β-H 4-OMe CF3 CH2 0
22 OMe β-H 4-OMe Me O 0
23 F β-H 4-OMe Me O 0
24 OMe β-H 4-OMe Me S 0
25 OMe β-H 4-OMe Me SO2 0
26 OMe β-H H Me CH2 1
27 OMe β-H 4-OMe CH2OH CH2 0
28 OMe β-H 3-F, 4-OMe Me CH2 0
29 OMe β-H 3-F, 4-OMe CH2OH CH2 0
30 OMe β-H 4-OCF3 Me CH2 0
31 OMe β-H 4-OCF3 CH2OH CH2 0
32 OMe β-H 4-OCF3 CH2OH SO2 0
33 OMe β-H 3-F, 4-OCF3 CH2OH CH2 0
a

α-H refers to the (3R,3aS)-rel-diastereomer; β-H refers to the (3R,3aR)-rel-diastereomer.