Table 3.
Risk of Colorectal Cancer According to Duration of Bisphosphonate Use
| Variable | No. of Years of Regular Bisphosphonate Use |
Ptrend | ||||||
|---|---|---|---|---|---|---|---|---|
| 0(686/698,986)* | 1-2(63/63,563)* |
3-4(32/31,124)* |
≥5(20/27,004)* |
|||||
| HR | 95% CI | HR | 95% CI | HR | 95% CI | |||
| Age adjusted | 1.00 | 1.10 | 0.85 to 1.44 | 0.99 | 0.68 to 1.42 | 0.78 | 0.49 to 1.23 | .44 |
| Multivariable adjusted† | 1.00 | 1.24 | 0.94 to 1.64 | 1.16 | 0.79 to 1.69 | 0.97 | 0.60 to 1.56 | .79 |
Abbreviation: HR, hazard ratio.
No. of cases/No. of person-years.
Adjusted for age (years), race (white, nonwhite), body mass index (< 21, 21-22.9, 23-24.9, 25-29.9, ≥ 30 kg/m2), smoking status (current, past, never), family history (sibling, mother, or father) of colon cancer (yes, no), history of osteoporosis (yes, no), regular aspirin use (≥ two standard tablets per week), hormone replacement therapy (never, past, current), regular statin use (yes, no), total daily calcium intake (< 600, 600-899, 900-1,200, > 1,200 mg/d), vitamin D intake (< 400, 400-600, > 600 IU/d), folate intake (quintiles), red meat intake (< two per week, two to four per week, five to six per week, at least one per day), total daily alcohol intake (< 5, 5-15, > 15 g/d), level of physical activity (< 1.7, 1.7-4.5, 4.6-10.5, 10.6-22.1, > 22.1 metabolic equivalents per week), history of polyps (yes, no), and history of screening (yes, no).