Figure 2. IGHV gene repertoire in CLL and relation to BCR IG stereotypy.

Relative frequency (%) of the 10 predominant IGHV genes in CLL (A), and their distribution among the “stereotyped” and “heterogeneous” subsets (B). The majority of IGHV3-21 cases carry stereotyped B cell receptors, whereas most rearrangements of the IGHV3-23 gene exhibit heterogeneity within their VH CDR3s. Based on data from Agathangelidis et al. 2012.⁴⁷