Table 1. National treatment schedules for 2nd stage T.b. rhodesiense HAT.
Uganda | Tanzania | Kenya | Malawi | |
Suramin pre-treatment (mg/kg) | ||||
1st dose | 5 | 5 | NA | 5 |
2nd dose | 20 | NA | 20 | |
Melarsoprol treatment (mg/kg) | ||||
1st series | 0.5, 0.72, 1.08 | 2.2, 2.52, 2.88 | 3.6, 3.6, 3.6 | 3.6, 3.6, 3.6 |
2nd series | 1.44, 2.80, 2.2 | 2.88, 3.24, 3.6 | 3.6, 3.6, 3.6 | 3.6, 3.6, 3.6 |
3rd series | 2.52, 2.88, 3.24 | 3.6, 3.6, 3.6 | 3.6, 3.6, 3.6 | 3.6, 3.6, 3.6 |
4th series | 3.6, 3.6, 3.6 | 3.6, 3.6, 3.6 | ||
Total melarsoprol (mg/kg) | 27 | 28.08 | 43.2 | 32.4 |
Hospitalization time (days) | 29 | 27 | 33 | 26 |
NA:not applicable; i.v. melarsoprol injections at 24 hours intervals per series, each series spaced by 5 to 7 days resting periods; further variations of the schedules at local level.