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. 2012 Mar 1;142(3):663–672. doi: 10.1378/chest.11-2746

Figure 1.

Figure 1.

mRNA and micro RNA (miRNA) expression in the lungs from patients with COPD. A, Individual data derived from reverse transcriptase polymerase chain reaction (RT-PCR) analysis of HIF-1α mRNA expression in the lungs from patients with COPD. B, Individual data derived from RT-PCR analysis of VEGF mRNA expression in the lungs from patients with COPD. C, Individual data derived from RT-PCR analysis of miR-34a miRNA expression in the lungs from patients with COPD. D, Individual data derived from RT-PCR analysis of miR-199a-5p miRNA expression in the lungs from patients with COPD. VEGF mRNA expression was significantly decreased in the lungs of patients with COPD compared with the expression of control (functionally and histologically normal) lungs. The expression of miR-34a and miR-199a-5p was significantly increased in the lungs from patients with COPD compared with the expression in control lungs. Data are expressed as mean ± SE *P < .05 vs no COPD. HIF-1α = hypoxia inducible factor-1α; VEGF = vascular endothelial growth factor.

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