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. 2012 Mar 1;142(3):663–672. doi: 10.1378/chest.11-2746

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© 2012 American College of Chest Physicians

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Figure 4. — Correlations of AKT phosphorylation and correlation between miR-34a and p53 and between miR-199a-5p and HIF-1α in the lungs from patients with COPD. Correlation analysis between pAKT, HIF-1α, or p53 protein expression, and miR-34a or miR-199a-5p expression. A, A strong correlation was seen between p53 protein expression and miR-34a expression. B, A moderate correlation was seen between HIF-1α protein expression and miR-199a-5p expression. C, A moderate inverse correlation was seen between pAKT and miR34a. ○ = no COPD, = mild COPD, = moderate COPD, and ● = severe COPD. See Figure 1 and 3 legends for expansion of abbreviations.

Inline graphic — Correlations of AKT phosphorylation and correlation between miR-34a and p53 and between miR-199a-5p and HIF-1α in the lungs from patients with COPD. Correlation analysis between pAKT, HIF-1α, or p53 protein expression, and miR-34a or miR-199a-5p expression. A, A strong correlation was seen between p53 protein expression and miR-34a expression. B, A moderate correlation was seen between HIF-1α protein expression and miR-199a-5p expression. C, A moderate inverse correlation was seen between pAKT and miR34a. ○ = no COPD, = mild COPD, = moderate COPD, and ● = severe COPD. See Figure 1 and 3 legends for expansion of abbreviations.

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