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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Nat Neurosci. 2012 Jun;15(6):845–852. doi: 10.1038/nn.3089

FIGURE 3. Phosphorylation of S868 on GluK2 increases surface expression of KARs.

FIGURE 3

a. PMA (1 μM) caused an increase in the KAR EPSC amplitude in hippocampal slices. Responses for each cell are normalised to the first 10 minutes. Example traces are taken as the average between 5-10 minutes (black) and 20-25 minutes (grey). Scale bars are 50 pA and 50 ms. b. Chelerythrine (5 μM) caused a decrease in the KAR EPSC amplitude. c. PMA caused an increase in the KAR current evoked from HEK cells expressing WT GluK2. Scale bars are 100 pA and 500 ms. d. PMA caused an increase in the KAR current evoked from HEK cells expressing K886R GluK2. e. Comparison of the timecourse of PMA-induced increase in KAR current between WT and K886R expressing HEK cells. f. PMA application did not increase the KAR current evoked from HEK cells containing S868A GluK2. Data are plotted as mean ± s.e.m.