Fig. 1.
Increased tumorigenesis in Ikkβ(EE)IEC/Apc+/ΔIEC mice. (A) Survival rates of the indicated strains of mice. (B) Tumor numbers and tumor load (the sum of tumor diameters) in the proximal SI (proximal 6 cm, herein referred as duodenum) and colon of Ikkβ(EE)IEC/Apc+/ΔIEC and Apc+/ΔIEC mice. (C) IHC for β-catenin performed on paraffin sections of tumors from 3-mo-old mice of the indicated genotypes. (D) IHC for β-catenin performed on “Swiss-roll” preparations of 1-mo-old mice of the indicated genotypes. Bar graphs show the numbers of β-catenin+ foci in 4- to 6-wk-old mice.