Fig. 1.

Functional convergence versus direct convergence of CHD datasets. Risk and responder datasets are indicated by green, gold, and blue circles or ellipses, respectively. Numbers represent theoretical gene counts and are different for datasets with the same name in A and B. (A) Illustrates six risk and responder datasets with different genes that are all functionally converging on a predefined developmental program of the ventricular septum (black circle, containing a total of 278 genes). The example illustrates how different risk and responder datasets can contain many genes involved in a common polygenic developmental program (bolded black and red numbers), while only sparsely overlapping with each other (red numbers). (B) Theoretical example of direct convergence, where the risk and responder datasets can be directly overlapped to reveal a common subset of genes (red numbers).