Fig. 2.

Functional convergence of CHD risk and responder datasets in cardiac developmental networks. (A–C) Functional convergence was analyzed in predefined developmental programs (11), deduced from protein–protein interaction networks driving the development of the outflow tract (A), ventricular septum (B), and atrial septum (C). Circles represent gene-encoded proteins (gene names viewable with the Adobe zoom tool or at www.cbs.dtu.dk/suppl/dgf/). Lines represent protein–protein interactions. Colors indicate datasets of Mendelian risk genes, SNPs, or Mendelian responder genes (green), CNVs and translocations from cohort A or B (gold), or environmental target or responder genes (blue). Red circles indicate proteins belonging to more than one dataset.