Study design for drug treatment studies in M. tuberculosis-infected macaques. (A) Drug treatment of latently infected monkeys, with subsequent anti-TNF antibody (adalimumab) treatment to induce reactivation, with necropsy. (B) Drug treatment of active tuberculosis monkeys, with necropsy. H, INH; R, RIF; Z, PZA; E, ETH; M, MTZ.