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. 2012 Sep 6;8(9):e1002669. doi: 10.1371/journal.pcbi.1002669

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© 2012 Torres-Sosa et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Although all networks in the final population have the same attractor landscape, they are structurally not completely identical to each other. Here we show three networks randomly chosen from the final population (A, B and C). The image in D is a superposition of all the networks in that population. The link persistence is defined as , where is the number of networks in the final population in which the nodes and were connected. The links in D have been colored according to their persistence (white for and red for ). It is apparent that the highly persistent links mostly belong to the global regulators (hubs). This strongly suggests that the global regulators play an important role in determining the phenotypic landscape of the population.

Inline graphic — Although all networks in the final population have the same attractor landscape, they are structurally not completely identical to each other. Here we show three networks randomly chosen from the final population (A, B and C). The image in D is a superposition of all the networks in that population. The link persistence is defined as , where is the number of networks in the final population in which the nodes and were connected. The links in D have been colored according to their persistence (white for and red for ). It is apparent that the highly persistent links mostly belong to the global regulators (hubs). This strongly suggests that the global regulators play an important role in determining the phenotypic landscape of the population.