Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Sep 6;8(9):e1002669. doi: 10.1371/journal.pcbi.1002669

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 Torres-Sosa et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

This type of mutation affects how the regulators of a given target gene (inputs to node ) jointly control its output. (A) Gene has acquired a new binding site, represented by the leftmost square in green. (B) The new binding site is occupied by one of the already existing regulators of . (C) The new binding site is occupied by a completely different gene (green circle) that thus becomes a new regulator of . (D) Another mutation in the regulatory region is the deletion of existing binding sites. Here, the deleted site belongs to a regulator for which there are alternative binding sites left which thus remains a regulator. (E) Conversely, the removal of the binding site can completely break the regulatory interaction between and the respective regulator. Deletion of binding sites that can leave a given gene with no regulators at all are not allowed.

Inline graphic — This type of mutation affects how the regulators of a given target gene (inputs to node ) jointly control its output. (A) Gene has acquired a new binding site, represented by the leftmost square in green. (B) The new binding site is occupied by one of the already existing regulators of . (C) The new binding site is occupied by a completely different gene (green circle) that thus becomes a new regulator of . (D) Another mutation in the regulatory region is the deletion of existing binding sites. Here, the deleted site belongs to a regulator for which there are alternative binding sites left which thus remains a regulator. (E) Conversely, the removal of the binding site can completely break the regulatory interaction between and the respective regulator. Deletion of binding sites that can leave a given gene with no regulators at all are not allowed.