Figure 7. Effects of intravitreal bumetanide injections on the responses of NOT-DTN neurons to moving light (ON) and dark (OFF) edges.

Comparison of the activity during ON (A) and OFF (B) moving edge stimulation in preferred (PD, grey bars) and non-preferred (NPD, white bars) directions prior to (control) and after intravitreous injection of the drug (bumetanide). Horizontal lines indicate the median, boxes the 25–75%, whiskers the 10–90%, and black dots the 5–95 percentiles of the non-parametric statistical comparison. Bumetanide reduces responses in preferred direction and enhances responses in the non preferred direction, especially in the responses to the OFF stimulus.