Table 1. Association of KLK4 SNPs and prostate cancer risk.
| SNP | Genotype | Controls | Cases | Adjusted | |
| Chr positiona | n (%) | n (%) | OR (95% CI) | P | |
| rs17714461 | GG | 1000 (78.9) | 984 (77.5) | 1.00 | |
| 56116918 | GA | 255 (20.1) | 277 (21.8) | 1.11 (0.91–1.34) | 0.307 |
| AA | 12 (0.9) | 9 (0.7) | 0.77 (0.32–1.84) | 0.556 | |
| Per A allele | 1.07 (0.89–1.28) | 0.477 | |||
| rs17714450 | GG | 1286 (99.3) | 1250 (98.7) | 1.00 | |
| 56115669 | GA | 9 (0.7) | 17 (1.3) | 1.94 (0.86–4.37) | 0.112 |
| AA | 0 (0.0) | 0 (0.0) | N/A | N/A | |
| Per A allele | 1.94 (0.86–4.37) | 0.112 | |||
| rs8101572 | AA | 395 (30.5) | 389 (30.7) | 1.00 | |
| 56115440 | AC | 619 (47.8) | 634 (50.0) | 1.03 (0.86–1.24) | 0.726 |
| CC | 281 (21.7) | 245 (19.3) | 0.87 (0.70–1.09) | 0.236 | |
| Per C allele | 0.94 (0.85–1.05) | 0.306 | |||
| rs8100631 | GG | 489 (37.8) | 474 (37.4) | 1.00 | |
| 56115358 | GA | 586 (45.3) | 592 (46.7) | 1.03 (0.87–1.22) | 0.731 |
| AA | 220 (17.0) | 201 (15.9) | 0.93 (0.74–1.17) | 0.535 | |
| Per A allele | 0.98 (0.87–1.09) | 0.678 | |||
| rs268920c | CC | 1295 (100.0) | 1267 (99.9) | 1.00 | |
| 56114746 | CG | 0 (0.0) | 1 (0.1) | N/A | N/A |
| GG | 0 (0.0) | 0 (0.0) | N/A | N/A | |
| Per G allele | N/A | N/A | |||
| rs10427094 | CC | 1130 (88.9) | 1113 (90.7) | 1.00 | |
| 56114689 | CT | 137 (10.8) | 112 (9.1) | 0.84 (0.64–1.09) | 0.183 |
| TT | 4 (0.3) | 2 (0.2) | 0.53 (0.10–2.92) | 0.466 | |
| Per T allele | 0.83 (0.64–1.06) | 0.138 | |||
| rs268921 | CC | 477 (36.9) | 467 (36.8) | 1.00 | |
| 56114503 | CG | 592 (45.7) | 594 (46.8) | 1.01 (0.85–1.20) | 0.891 |
| GG | 225 (17.4) | 207 (16.3) | 0.93 (0.74–1.17) | 0.518 | |
| Per G allele | 0.97 (0.87–1.09) | 0.613 | |||
| rs268923 | AA | 416 (33.6) | 450 (36.9) | 1.00 | |
| 56114028 | AT | 617 (49.9) | 593 (48.6) | 0.88 (0.74–1.05) | 0.159 |
| TT | 204 (16.5) | 176 (14.4) | 0.79 (0.62–1.01) | 0.059 | |
| Per T allele | 0.89 (0.79–1.00) | 0.045 | |||
| rs10419776 | CC | 940 (77.9) | 692 (75.1) | 1.00 | |
| 56113695 | CG | 249 (20.6) | 216 (23.5) | 1.17 (0.95–1.44) | 0.137 |
| GG | 18 (1.5) | 13 (1.4) | 0.90 (0.44–1.86) | 0.780 | |
| Per G allele | 1.11 (0.93–1.34) | 0.251 | |||
| rs56112930 | CC | 1250 (98.7) | 1234 (99.5) | 1.00 | |
| 56112295 | CT | 16 (1.3) | 6 (0.5) | 0.37 (0.14–0.96) | 0.040 |
| TT | 0 (0.0) | 0 (0.0) | N/A | N/A | |
| Per T allele | 0.37 (0.14–0.96) | 0.040 | |||
| rs7248321 b | AA | 1182 (88.1) | 1185 (90.7) | 1.00 | |
| 56110317 | AG | 156 (11.6) | 121 (9.3) | 0.78 (0.60–1.00) | 0.048 |
| GG | 3 (0.2) | 1 (0.1) | 0.35 (0.04–3.35) | 0.359 | |
| Per G allele | 0.77 (0.60–0.98) | 0.033 | |||
| rs2569526 | AA | 1259 (99.0) | 1225 (99.7) | 1.00 | |
| 56106299 | AG | 13 (1.0) | 4 (0.3) | 0.34 (0.11–1.06) | 0.062 |
| GG | 0 (0.0) | 0 (0.0) | N/A | N/A | |
| Per G allele | 0.34 (0.11–1.06) | 0.062 | |||
| rs2978642 | TT | 747 (57.7) | 731 (57.8) | 1.00 | |
| 56105718 | TA | 466 (36.0) | 452 (35.7) | 0.99 (0.84–1.17) | 0.936 |
| AA | 81 (6.3) | 82 (6.5) | 1.03 (0.74–1.42) | 0.858 | |
| Per A allele | 1.00 (0.88–1.14) | 0.947 | |||
| rs198969b | GG | 366 (27.3) | 349 (26.7) | 1.00 | |
| 56105614 | GC | 640 (47.8) | 642 (49.1) | 1.06 (0.88–1.27) | 0.557 |
| CC | 334 (24.9) | 316 (24.2) | 0.98 (0.79–1.22) | 0.876 | |
| Per C allele | 0.99 (0.89–1.10) | 0.897 | |||
| rs2242669 | CC | 860 (68.0) | 846 (68.3) | 1.00 | |
| 56105602 | CT | 364 (28.8) | 358 (28.9) | 1.00 (0.84–1.19) | 0.995 |
| TT | 41 (3.2) | 35 (2.8) | 0.85 (0.54–1.35) | 0.500 | |
| Per T allele | 0.97 (0.84–1.13) | 0.708 | |||
| rs198968b | CC | 830 (62.8) | 838 (64.4) | 1.00 | |
| 56105140 | CT | 432 (32.7) | 421 (32.4) | 0.96 (0.81–1.13) | 0.637 |
| TT | 59 (4.5) | 42 (3.2) | 0.71 (0.47–1.07) | 0.100 | |
| Per T allele | 0.91 (0.80–1.05) | 0.195 | |||
| rs198967 | CC | 1292 (99.9) | 1265 (99.8) | ||
| 56104833 | CT | 1 (0.1) | 3 (0.2) | 3.73 (0.39–36.07) | 0.255 |
| TT | 0 (0.0) | 0 (0.0) | N/A | N/A | |
| Per T allele | 3.73 (0.39–36.07) | 0.255 | |||
| rs1654551 | TT | 1060 (81.9) | 1082 (85.3) | 1.00 | |
| 56104480 | TG | 227 (17.5) | 181 (14.5) | 0.79 (0.64–0.97) | 0.028 |
| GG | 7 (0.5) | 5 (0.4) | 0.67 (0.21–2.13) | 0.499 | |
| Per G allele | 0.79 (0.65–0.97) | 0.023 | |||
| rs1654552 | GG | 403 (31.1) | 376 (29.7) | 1.00 | |
| 56104478 | GT | 603 (46.6) | 637 (50.3) | 1.15 (0.96–1.37) | 0.140 |
| TT | 288 (22.3) | 254 (20.0) | 0.95 (0.76–1.19) | 0.658 | |
| Per T allele | 0.99 (0.89–1.10) | 0.847 | |||
| rs2242670b | CC | 418 (31.2) | 359 (27.4) | 1.00 | |
| 56104127 | CT | 634 (47.4) | 674 (51.5) | 1.24 (1.04–1.48) | 0.017 |
| TT | 286 (21.4) | 277 (21.1) | 1.12 (0.90–1.39) | 0.309 | |
| Per T allele | 1.07 (0.96–1.19) | 0.210 | |||
| rs198966 | CC | 1294 (99.9) | 1265 (99.8) | 1.00 | |
| 56103822 | CT | 1 (0.1) | 2 (0.2) | 2.47 (0.22–27.42) | 0.460 |
| TT | 0 (0.0) | 1 (0.1) | N/A | N/A | |
| Per T allele | 3.39 (0.45–25.58) | 0.236 | |||
| rs34626614 | GG | 1294 (99.9) | 1267 (99.9) | 1.00 | |
| 56103563 | GA | 1 (0.1) | 1 (0.1) | 1.18 (0.07–18.86) | 0.909 |
| AA | 0 (0.0) | 0 (0.0) | N/A | N/A | |
| Per A allele | 1.18 (0.07–18.86) | 0.909 | |||
| rs2569527 | AA | 1274 (98.4) | 1255 (99.0) | 1.00 | |
| 56103448 | AC | 21 (1.6) | 13 (1.0) | 0.62 (0.31–1.25) | 0.186 |
| CC | 0 (0.0) | 0 (0.0) | N/A | N/A | |
| Per C allele | 0.62 (0.31–1.25) | 0.186 | |||
| rs189903c | CC | 1258 (100.0) | 1184 (99.8) | 1.00 | |
| 56103377 | CT | 0 (0.0) | 2 (0.2) | N/A | N/A |
| TT | 0 (0.0) | 0 (0.0) | N/A | N/A | |
| Per T allele | N/A | N/A | |||
| rs2979451b | AA | 686 (52.0) | 625 (48.2) | 1.00 | |
| 56103200 | AG | 507 (38.4) | 562 (43.3) | 1.21 (1.03–1.42) | 0.021 |
| GG | 127 (9.6) | 111 (8.6) | 0.96 (0.73–1.27) | 0.772 | |
| Per G allele | 1.06 (0.95–1.20) | 0.298 | |||
| rs1701929b | TT | 703 (52.8) | 721 (55.0) | 1.00 | |
| 56103141 | TC | 540 (40.6) | 520 (39.6) | 0.94 (0.80–1.10) | 0.411 |
| CC | 88 (6.6) | 71 (5.4) | 0.77 (0.56–1.08) | 0.130 | |
| Per C allele | 0.91 (0.80–1.03) | 0.135 | |||
| rs7255024 | CC | 1070 (88.2) | 1083 (88.3) | 1.00 | |
| 56103075 | CA | 140 (11.5) | 140 (11.4) | 0.99 (0.77–1.27) | 0.912 |
| AA | 3 (0.2) | 4 (0.3) | 1.36 (0.30–6.12) | 0.687 | |
| Per A allele | 1.00 (0.79–1.27) | 0.986 | |||
| rs1654553b | AA | 390 (29.2) | 344 (26.3) | 1.00 | |
| 56102928 | AG | 626 (46.9) | 679 (51.9) | 1.24 (1.04–1.49) | 0.019 |
| GG | 320 (24.0) | 286 (21.8) | 1.03 (0.83–1.27) | 0.821 | |
| Per G allele | 1.02 (0.92–1.14) | 0.687 | |||
| rs2235091b | TT | 583 (43.6) | 520 (39.6) | 1.00 | |
| 56102283 | TC | 563 (42.1) | 609 (46.4) | 1.21 (1.02–1.42) | 0.025 |
| CC | 192 (14.3) | 183 (13.9) | 1.06 (0.84–1.35) | 0.606 | |
| Per C allele | 1.07 (0.96–1.20) | 0.208 | |||
| rs35945487 | CC | 1262 (97.5) | 1238 (97.6) | 1.00 | |
| 56102098 | CT | 32 (2.5) | 30 (2.4) | 0.93 (0.56–1.55) | 0.790 |
| TT | 0 (0.0) | 0 (0.0) | N/A | N/A | |
| Per T allele | 0.93 (0.56–1.55) | 0.790 | |||
| rs73042387 | GG | 884 (73.7) | 901 (74.6) | 1.00 | |
| 56101983 | GA | 291 (24.3) | 287 (23.8) | 0.96 (0.80–1.16) | 0.686 |
| AA | 25 (2.1) | 20 (1.7) | 0.80 (0.44–1.45) | 0.460 | |
| Per A allele | 0.94 (0.80–1.11) | 0.484 | |||
| rs1139132 | CC | 540 (44.9) | 488 (40.2) | 1.00 | |
| 56101575 | CA | 499 (41.4) | 563 (46.4) | 1.24 (1.04–1.47) | 0.015 |
| AA | 165 (13.7) | 163 (13.4) | 1.08 (0.84–1.38) | 0.555 | |
| Per A allele | 1.09 (0.97–1.22) | 0.152 | |||
| rs1701927 | AA | 882 (68.1) | 906 (71.5) | 1.00 | |
| 56100654 | AC | 374 (28.9) | 336 (26.5) | 0.87 (0.73–1.03) | 0.110 |
| CC | 39 (3.0) | 26 (2.1) | 0.65 (0.39–1.07) | 0.091 | |
| Per C allele | 0.85 (0.73–0.98) | 0.030 | |||
| rs1701926 | TT | 863 (68.3) | 871 (71.1) | 1.00 | |
| 56100570 | TG | 363 (28.7) | 332 (27.1) | 0.91 (0.76–1.08) | 0.273 |
| GG | 37 (2.9) | 22 (1.8) | 0.58 (0.34–1.00) | 0.050 | |
| Per G allele | 0.86 (0.74–1.00) | 0.058 | |||
| rs2569530 | GG | 334 (30.1) | 274 (25.6) | 1.00 | |
| 56100420 | GT | 509 (45.9) | 553 (51.6) | 1.33 (1.09–1.62) | 0.006 |
| TT | 265 (23.9) | 244 (22.8) | 1.12 (0.89–1.42) | 0.332 | |
| Per T allele | 1.07 (0.95–1.20) | 0.258 | |||
| rs1090649 | CC | 860 (68.3) | 871 (71.0) | 1.00 | |
| 56098343 | CG | 358 (28.4) | 333 (27.2) | 0.92 (0.77–1.10) | 0.344 |
| GG | 41 (3.3) | 22 (1.8) | 0.53 (0.31–0.89) | 0.017 | |
| Per G allele | 0.86 (0.73–1.00) | 0.044 | |||
| rs11881354 | AA | 557 (44.1) | 504 (40.6) | 1.00 | |
| 56097941 | AG | 531 (42.0) | 574 (46.3) | 1.19 (1.00–1.41) | 0.045 |
| GG | 176 (13.9) | 162 (13.1) | 1.01 (0.79–1.29) | 0.945 | |
| Per G allele | 1.05 (0.94–1.18) | 0.394 | |||
| rs806019 | CC | 880 (68.0) | 903 (71.2) | 1.00 | |
| 56097794 | CG | 375 (29.0) | 339 (26.7) | 0.87 (0.73–1.04) | 0.129 |
| GG | 39 (3.0) | 26 (2.1) | 0.65 (0.39–1.07) | 0.092 | |
| Per G allele | 0.85 (0.73–0.99) | 0.036 | |||
| rs806020 | GG | 365 (28.9) | 326 (26.4) | 1.00 | |
| 56097620 | GA | 591 (46.9) | 632 (51.2) | 1.21 (1.00–1.46) | 0.049 |
| AA | 305 (24.2) | 277 (22.4) | 1.03 (0.82–1.28) | 0.802 | |
| Per A allele | 1.02 (0.91–1.14) | 0.704 | |||
| rs806021 | AA | 374 (29.6) | 338 (27.3) | 1.00 | |
| 56097485 | AG | 592 (46.9) | 625 (50.5) | 1.17 (0.97–1.41) | 0.093 |
| GG | 297 (23.5) | 274 (22.2) | 1.03 (0.82–1.28) | 0.802 | |
| Per G allele | 1.02 (0.92–1.14) | 0.696 | |||
| rs806022 | GG | 378 (29.2) | 332 (26.2) | 1.00 | |
| 56096999 | GT | 610 (47.1) | 650 (51.3) | 1.22 (1.01–1.46) | 0.037 |
| TT | 306 (23.6) | 285 (22.5) | 1.07 (0.86–1.33) | 0.559 | |
| Per T allele | 1.04 (0.93–1.16) | 0.473 | |||
| rs806023 | AA | 379 (29.4) | 342 (27.1) | 1.00 | |
| 56096896 | AG | 608 (47.1) | 640 (50.7) | 1.17 (0.97–1.40) | 0.097 |
| GG | 303 (23.5) | 281 (22.2) | 1.03 (0.83–1.29) | 0.766 | |
| Per G allele | 1.02 (0.92–1.14) | 0.669 | |||
| rs2569535 | GG | 1278 (98.9) | 1256 (99.5) | 1.00 | |
| 56096639 | GC | 14 (1.1) | 6 (0.5) | 0.48 (0.18–1.24) | 0.130 |
| CC | 0 (0.0) | 0 (0.0) | N/A | N/A | |
| Per C allele | 0.48 (0.18–1.24) | 0.130 | |||
| rs1701941 | TT | 357 (27.8) | 316 (25.0) | 1.00 | |
| 56096032 | TA | 606 (47.9) | 650 (51.4) | 1.19 (0.99–1.44) | 0.065 |
| AA | 312 (24.3) | 298 (23.6) | 1.08 (0.87–1.35) | 0.478 | |
| Per A allele | 1.04 (0.94–1.17) | 0.441 | |||
| rs1654513 | AA | 550 (42.5) | 555 (43.8) | 1.00 | |
| 56094494 | AG | 593 (45.8) | 578 (45.6) | 0.97 (0.82–1.14) | 0.701 |
| GG | 152 (11.7) | 135 (10.6) | 0.88 (0.68–1.14) | 0.341 | |
| Per G allele | 0.95 (0.84–1.07) | 0.374 | |||
| rs8104538 | TT | 621 (48.0) | 606 (47.8) | 1.00 | |
| 56093609 | TC | 542 (41.9) | 535 (42.2) | 1.00 (0.85–1.18) | 0.978 |
| CC | 132 (10.2) | 126 (9.9) | 0.98 (0.75–1.28) | 0.883 | |
| Per C allele | 0.99 (0.88–1.12) | 0.926 | |||
| rs10409668c | CC | 1295 (100.0) | 1267 (99.9) | 1.00 | |
| 56093213 | CT | 0 (0.0) | 1 (0.1) | N/A | N/A |
| TT | 0 (0.0) | 0 (0.0) | N/A | N/A | |
| Per T allele | N/A | N/A | |||
| rs1560719 | TT | 521 (40.4) | 475 (38.3) | 1.00 | |
| 56092648 | TC | 569 (44.1) | 581 (46.8) | 1.12 (0.95–1.33) | 0.178 |
| CC | 201 (15.6) | 185 (14.9) | 1.01 (0.80–1.27) | 0.956 | |
| Per C allele | 1.03 (0.92–1.15) | 0.614 | |||
| rs2739493 | TT | 489 (37.8) | 435 (34.4) | 1.00 | |
| 56092488 | TG | 583 (45.1) | 609 (48.1) | 1.17 (0.98–1.39) | 0.076 |
| GG | 221 (17.1) | 221 (17.5) | 1.11 (0.88–1.39) | 0.368 | |
| Per G allele | 1.07 (0.96–1.20) | 0.210 | |||
| rs1701934 | GG | 1283 (99.1) | 1256 (99.1) | 1.00 | |
| 56092213 | GA | 12 (0.9) | 11 (0.9) | 0.97 (0.43–2.21) | 0.944 |
| AA | 0 (0.0) | 1 (0.1) | N/A | N/A | |
| Per A allele | 1.15 (0.54–2.46) | 0.716 | |||
| rs1560723 | TT | 1282 (99.1) | 1255 (99.1) | 1.00 | |
| 56092168 | TC | 12 (0.9) | 11 (0.9) | 0.97 (0.43–2.21) | 0.944 |
| CC | 0 (0.0) | 1 (0.1) | N/A | N/A | |
| Per C allele | 1.15 (0.54–2.46) | 0.716 | |||
| rs1701936 | CC | 1292 (99.8) | 1263 (99.7) | 1.00 | |
| 56091945 | CT | 3 (0.2) | 3 (0.2) | 1.17 (0.23–5.83) | 0.849 |
| TT | 0 (0.0) | 1 (0.1) | N/A | N/A | |
| Per T allele | 1.74 (0.47–6.42) | 0.405 | |||
| rs1654514 | AA | 1282 (99.0) | 1256 (99.1) | 1.00 | |
| 56091856 | AG | 13 (1.0) | 11 (0.9) | 0.89 (0.40–2.00) | 0.780 |
| GG | 0 (0.0) | 1 (0.1) | N/A | N/A | |
| Per G allele | 1.06 (0.50–2.24) | 0.871 | |||
| rs1701937 | CC | 1292 (99.8) | 1264 (99.7) | 1.00 | |
| 56091743 | CA | 3 (0.2) | 3 (0.2) | 1.17 (0.23–5.82) | 0.850 |
| AA | 0 (0.0) | 1 (0.1) | N/A | N/A | |
| Per A allele | 1.74 (0.47–6.41) | 0.406 |
SNP, single nucleotide polymorphism; chr, chromosome; n, number; OR, odds ratio; CI, confidence interval.
a
Co-ordinates from hg18.
b
tagSNP.
c
SNP too infrequent in these groups to calculate OR (95% CI).
Bold, SNPs displaying a Ptrend value <0.05.